Testicular atrophy, or the shrinking of the testicles, is a common and normal side effect of Testosterone Replacement Therapy (TRT).

Why Testicular Atrophy Occurs on TRT

When patients begin TRT, the body receives an external source of testosterone, which signals to the testes that they no longer need to produce testosterone on their own. As a result, the testicles may decrease in size over time—a process known as testicular atrophy. This atrophy is a typical response and should be expected as part of the therapy.

Testicular Discomfort During Atrophy

While testicular atrophy itself is generally painless, some men may experience discomfort during the initial stages. This discomfort can be more noticeable in individuals with poor mobility through the hips, glutes, pelvic floor, and groin muscles. Tightness or imbalances in these areas can exacerbate the sensation of discomfort as the body adjusts to the changes brought on by TRT.

Managing Discomfort

If a patient experiences testicular discomfort during TRT, consider the following strategies to alleviate the symptoms:

• Improve Mobility: Engage in regular stretching and mobility exercises focusing on the hips, glutes, pelvic floor, and groin areas. This can help alleviate any tension or tightness that might be contributing to discomfort.
• Stay Active: Incorporating regular physical activity can improve circulation and flexibility, which may help reduce discomfort associated with testicular atrophy.
• Monitor Symptoms: While some discomfort is normal during the initial stages of atrophy, it's important to monitor the symptoms. If the discomfort persists or worsens, patients should consult their local GP to discuss and investigate if there are any other issues with the testicles that could be worsening the discomfort of atrophy