Some patients on TRT can experience high estrogen (above 200 pmol/L). This is due to excess aromatisation - where an excess amount of testosterone is converted into estrogen.

Common causes of high estrogen:

• Excess body fat (above 16%)
• Undiagnosed sleep apnea
• Insulin resistance
• Alcohol consumption
• Liver issues
• Lack of cardiovascular exercise

To treat elevated estrogen, it is best to treat the root cause (listed above). However our doctors also typically prescribe a low dose of anastrozole, an aromatase inhibitor that helps reduce the conversion of testosterone to estrogen. A common dosage is 0.5 mg per week, which is usually effective in keeping estrogen levels within a normal range (below 200 pmol/L).

🧬 Estrogen (E2) Management

Estrogen (E2)

• Goal is between 70 - 200 pmol/L
• Some individuals can be higher with no negative estrogenic side effects and feel great, but some men will see reversal of benefits, and or negative side effects
• Why excess aromatisation in some patients? Excess body fat, liver issues, insulin resistance, lack of cardiovascular exercise or genetic

Important